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It plays a key role in maintaining intracellular FA homeostasis by regulating the transcription of FAO-related enzymes in mitochondria and peroxisomes, and modulates cellular FA uptake through regulating the expression of CD36 and CPT1 ( PGC-1 is a key regulator of mitochondrial biogenesis ( + levels, thereby promoting mitochondrial biogenesis and mitophagy

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Thereby, they exert multi-link modulation on the complex pathological network of migraine, which stands in sharp contrast to existing mainstream single-target or highly specific targeted drugs